A．Type 2 diabetes is caused by a combination of peripheral resistance to insulin action and an inadequate secretory response by the pancreatic beta cells.
B．In type 2 diabetes, there may be fibrosis and amyloid deposition in the islets in end stage.
C．It takes the form of an amorphous, hyaline thickening of the wall of the arterioles.
D．In type 2 diabetes, there is frequently a lymphocytic infiltration of the islets followed by a progressive loss of PP cells.